House and his team treat an underage runaway girl who refuses to identify her parents, and House takes a personal interest in the case. Meanwhile, Taub tries to find common ground with his infant daughters, Foreman’s affair takes a surprising turn, and House treats two brothers who engage in Civil War reenactments.

An Alzheimer’s patient visits Princeton Plainsboro as part of a hospital sanctioned drug trial, but when he inexplicably suffers from violent vomiting and an increasingly explosive temper, the team begins to unravel a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, House and Foreman butt heads, and Wilson treats a patient who claims to be in a chaste marriage

In the fall finale, a prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team’s preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient’s home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder. Also, Wilson becomes obsessed with proving that House is hiding something in his home, Park slowly comes out of her social shell and Foreman’s lack of romantic relationships piques the interest of Taub and Chase.

The team learns that their 14-year-old patient (guest star Madison Davenport) is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman’s firm opposition, House becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble. Meanwhile, Park tries to get Chase to admit the reason behind his recent obsession with grooming.

A teenage boy attempting to follow in his late father’s footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient (guest star John Scurti) who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.

A man (guest star Bamber) well-respected in his community suddenly collapses, and in the process of diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. But when the patient openly confesses his wrongdoings to his family and community, he compromises his chances of receiving the proper medical treatment. Meanwhile, House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.

A CEO (guest star Nouri) falls mysteriously ill just days before he signs a contract that would relocate his company’s entire labor force to China. House attempts to make an underhanded business transaction with his wealthy patient, but when the patient’s condition worsens, the team must work around the clock to save his life. Meanwhile, Park prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman, and Adams’ outlook on her patient’s business venture reveals her deeper feelings about loyalty.

House and Park treat a patient, Benjamin, who collapsed after making a surprisingly large charity donation, and come to suspect that the altruistic behavior is a symptom of a deeper disorder. When the patient offers to donate an organ for another patient, the doctors must convince Thirteen to help them confirm whether Benjamin is in his right mind or not. Meanwhile, House cons Dr. Adams into volunteering her time as part of his team.

Foreman brings House back to Princeton Plainsboro under parole to deal with an infected pair of lungs needed for a transplant patient. House is forced to work with a timid intern, the loss of his former team, Wilson’s hostility, and a new set of rules to find a cure in time to save the patient.

A year has passed since House ran Wilson’s car into Cuddy’s living room — and House has spent most of it in prison. Now House only has to stay out of trouble for five days to win his parole. However, events conspire against him when a mysterious ailment strikes a fellow prisoner while a gang leader wants House to procure pills for him.